Each uncoated tablet contains Cetirizine Dihydrochloride 10 mg.
Pharmacology: Cetirizine, an antihistamine, diminishes or abolishes the main action of histamine in the body by competitive, reversible blockade of histamine receptor sites on tissues. They do not inactivate histamine or prevent its synthesis or release. Histamine H1 receptors are responsible for vasodilation, increased capillary permeability, flare and itch reactions in the skin, and to some extent, contraction of smooth muscle in the bronchi and GI tract.
Pharmacodynamics: Absorption: Cetirizine is rapidly absorbed from the gastro-intestinal tract after oral administration, peak plasma concentrations being attained in about one hour. It is highly bound to plasma proteins and has a plasma half-life of about 11 hours. Traces of the drug have been detected in the breast milk. Cetirizine is excreted primarily in the urine.
For the symptomatic relief of allergy such as hay fever and urticaria.
Adult and children over 6 years old: 10 mg daily or 5 mg twice daily.
Children 2-6 years old: 5 mg daily or 2.5 mg twice daily.
Or as prescribed by a physician.
Cetirizine should not be given to premature infants or neonates; this group of patients has an increased susceptibility to antimuscarinic effects. Elderly patients are also more susceptible to many adverse effects of antihistamines, including antimuscarinic effects, sedation and hypotension.
Many antihistamines may cause drowsiness; patients so affected should not hive or operate machinery. Patients should avoid alcoholic drink. Some antihistamines have been associated with fetal abnormalities when taken during pregnancy.
Because of their muscarinic properties antihistamines should be used with care conditions such as closed-angle glaucoma urinary retention, prostatic hypertrophy or pyloroduodenal obstruction. Some antihistamines have been associated with fetal abnormalities when taken during pregnancy. Other adverse effects of antihistamines suggest caution in patients with epilepsy, severe cardiovascular disorders, or, for phenothiazines, in those with liver disorders.
Effects on the Ability to Drive or Operate Machinery: Many antihistamines cause drowsiness; patients so affected should not drive or operate machines. Patients should avoid alcoholic drinks.
Use in Pregnancy & Lactation: Some histamines are associated with fetal abnormalities when taken during pregnancy.
Some histamines are associated with fetal abnormalities when taken during pregnancy.
Traces of the drug have been found in breast milk. Therefore, pregnant and nursing women should take this drug strictly under medical advice.
The common side effects are sedation, drowsiness to deep sleep, constipation, and GI disturbances like nausea, vomiting, diarrhea and epigastic pain. Cetirizine may produce hypersensitivity reactions especially of skin. Photosensitivity has also been reported. Central sedation or antimuscarinic effect does not generally occur with Cetirizine.
Store at temperature not exceeding 30°C.
R06AE07 - cetirizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.