Amcinonide


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.1% cream/oint/lotion: Apply sparingly in a thin film to affected area bid or tid, depending on the severity of the condition.
Special Precautions
Childn. Pregnancy and lactation.
Adverse Reactions
Burning, itching, soreness, stinging, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin maceration and atrophy, striae, miliaria; HPA axis and growth suppression, Cushing’s syndrome, hyperglycaemia, glucosuria.
Patient Counseling Information
Do not use on the face, groin, or axilla. Avoid use of occlusive dressings in the presence of infected or weeping lesions.
MonitoringParameters
Perform urinary free cortisol and ACTH stimulation tests to monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression if drug is applied to a large surface area or under an occlusive dressing.
Lab Interference
May diminish the therapeutic effect of aldesleukin, corticorelin and hyaluronidase. May enhance the hyperglycaemic effect of ceritinib. May increase the adverse/toxic effect of deferasirox.
Action
Description: Amcinonide, a synthetic fluorinated glucocorticoid, has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release, and activity of endogenous chemical mediators of inflammation.
Pharmacokinetics:
Absorption: Adequately absorbed through intact skin and increases w/ inflammation/occlusion.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image
Amcinonide

Source: National Center for Biotechnology Information. PubChem Database. Amcinonide, CID=443958, https://pubchem.ncbi.nlm.nih.gov/compound/Amcinonide (accessed on Jan. 20, 2020)

Storage
Store between 15-30°C. Do not freeze.
ATC Classification
D07AC11 - amcinonide ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
References
Amcinonide Cream and Ointment (Taro Pharmaceuticals U.S.A., Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/09/2016.

Amcinonide Lotion (Fougera Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/09/2016.

Anon. Amcinonide (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/09/2016.

Buckingham R (ed). Amcinonide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/09/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Amcinonide (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 05/09/2016.

Disclaimer: This information is independently developed by MIMS based on Amcinonide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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