Cafonate

Cafonate

calcium folinate

Manufacturer:

Naprod Life Sciences

Distributor:

Atlanta Medicare
Concise Prescribing Info
Contents
Leucovorin Ca
Indications/Uses
Diminish toxicity & counteract the effects of inadvertent overdose of folic acid antagonist. In combination w/ 5-fluorouracil to prolong survival in the palliative treatment of patients w/ advanced colorectal carcinoma.
Dosage/Direction for Use
Folic acid antagonist overdose 5-15 mg daily by IM. Leucovorin Ca rescue after high-dose methotrexate therapy 15 mg/m2 body surface by IM or IV every 6 hr for 10 times initially 24 hr after the beginning of methotrexate infusion. Advanced colorectal cancer Administer 200 mg/m2 body surface by slow IV over a 3 min, followed by 5-fluorouracil at 370 mg/m2 body surface by IV or 20 mg/m2 body surface by IV inj, followed by 5-fluorouracil at 425 mg/m2 body surface by IV inj. Treatment repeated daily for 5 days. 5-day treatment course may be repeated at 4-wk (28 days) intervals.
Contraindications
Pernicious anemia & other megaloblastic anemia secondary to the lack of vit B12. Hematologic remission may occur while neurologic manifestations continue to progress.
Special Precautions
Should only be used w/ folic acid antagonist eg, methotrexate or fluoropyrimidines eg, 5-fluorouracil. Prefer parenteral administration if vomiting occurs. Enhanced toxicity of fluorouracil. Perform CBC w/ differential & platelets prior to each treatment w/ leucovorin Ca & 5-fluorouracil. Monitor electrolytes & liver function prior to treatment for the first 3 cycles, then prior to every other cycles. Defer treatment until WBCs are 4,000/mm3 & platelets 130,000/mm3. Follow-up physical exam prior to each treatment course & radiological exam. Discontinue when there is evidence of tumor progression. Pregnancy & lactation.
Adverse Reactions
Allergic sensitization ie, anaphylactoid reactions & urticaria; nausea & vomiting; seizures &/or syncope.
Drug Interactions
Antiepileptic effect of phenobarb, phenytoin & primidone & increased frequency of seizures in susceptible childn. Reduced efficacy of intrathecally administered methotrexate w/ high oral, IV or IM doses of leucovorin Ca.
ATC Classification
V03AF03 - calcium folinate ; Belongs to the class of detoxifying agents used in antineoplastic treatment.
Presentation/Packing
Form
Cafonate inj 3 mg/mL
Packing/Price
1's
Form
Cafonate inj 7.5 mg/mL
Packing/Price
1's
Form
Cafonate inj 15 mg/mL
Packing/Price
1's
Form
Cafonate inj 10 mg/mL
Packing/Price
1's
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