Tachycardia, HTN, nausea, vomiting, headache, burning sensation of the lips, mouth, throat, eyes and penis, salivation, lacrimation, tingling of the extremities, sensation of throat and chest constriction, sweating, conjunctivitis, muscle pains and spasm, rhinorrhoea, anxiety, abdominal pain, weakness, pain at the inj site, sterile abscess.
Monitor urine pH, renal function, infusion-related reactions, blood levels, Hb or haematocrit, Fe status.
Symptoms: Nausea, vomiting, malaise, lacrimation, salivation; burning sensation of lips, throat, mouth and eyes w/ headache; sense of throat and chest constriction; increased BP. Management: Admin SC diphenhydramine 50 mg or ephedrine 30 mg, or oral ephedrine 30-60 mg.
Potentially Fatal: May form toxic complexes w/ Fe supplements, cadmium, selenium, uranium.
Interferes w/ normal accumulation of iodine by the thyroid. Decreased iodine I 131 thyroidal uptake values.
Description: Dimercaprol chelates heavy metals e.g. gold, arsenic, mercury by competing w/ endogenous sulfhydryl groups on enzymes. This chelation prevents or reverses any inhibition of the sulfhydryl enzymes by the metal and forms a complex readily secreted in the kidneys. Pharmacokinetics: Absorption: Rapidly absorbed. Time to peak plasma concentration: 30-60 min. Distribution: Widely distributed to all tissues including the brain, w/ the highest concentrations in the liver and kidneys. Metabolism: Undergoes rapid hepatic metabolism and converted to inactive metabolites. Excretion: Via urine and bile. Essentially complete elimination w/in 4 hr of a single dose.
V03AB09 - dimercaprol ; Belongs to the class of antidotes. Used in the management of heavy metals poisoning.
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