Generic Medicine Info
Indications and Dosage
Atrial fibrillation, Atrial flutter
Adult: As fumarate: ≥60 kg: 1 mg over 10 min; <60 kg: 10 mcg/kg over 10 min. Stop infusion as soon as arrhythmia is terminated. Repeat the course if arrhythmia continues 10 min after completion of the 1st dose.
Elderly: Start at the lower end of dosing range.
Lactation. QTc interval >440 msec.
Special Precautions
Chronic atrial fibrillation. Correct hypokalaemia and hypomagnesaemia before initiation of therapy. Monitor ECG during and for at least 4 hr after infusion. Monitor for heart block. Pregnancy.
Adverse Reactions
Heart block, hypotension, hypertension, bradycardia, palpitations; headache; nausea, vomiting.
Potentially Fatal: Arrhythmias (including torsade de pointes).
IV/Parenteral: C
Symptoms: CNS depression, convulsions, arrhythmias. Management: Supportive. Avoid antiarrhythmics.
Drug Interactions
Additive prolongation of refractoriness with other antiarrhythmics. Increased proarrhythmic risks with drugs that prolong QT interval e.g. TCAs, phenothiazines, cisapride, sparfloxacin, gatifloxacin, moxifloxacin, erythromycin, astemizole. May mask signs of digoxin toxicity.
Description: Ibutilide is a methanesulfonanilide derivative class III antiarrhythmic agent. It prolongs repolarisation and refractoriness without affecting conduction. Antiarrhythmic action may result from activation of slow, inward current (predominantly sodium) at very low concentrations.
Onset: Approx 90 min after start of infusion.
Distribution: Protein-binding: About 40%.
Metabolism: Hepatic; via oxidation.
Excretion: Via urine (82%, 7% as unchanged drug and metabolites); via faeces (19%). 2-12 hr (elimination half-life).
Store at controlled room temperature 20-25°C (68-77°F).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Ibutilide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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