Discontinue if GI bleeding or ulceration occurs; at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. History of allergic conditions; ulcer; GI toxicity; cardiac disease. Patients w/ uncontrolled HTN, CHF, established ischaemic heart disease, peripheral arterial &/or cerebrovascular disease; risk factors for CV disease (eg, HTN, hyperlipidaemia, DM, smoking); asthma combined w/ chronic rhinitis & sinusitis, &/or nasal polyposis. Patients suffering from haematopoietic disorders, SLE or mixed connective tissue disease. Patients requiring concomitant low dose ASA; receiving diuretic therapy. Avoid use in case of varicella; if suspected w/ dengue fever. Masked symptoms of infectious diseases. Monitor for digestive disturbances, especially GI bleeding in patients w/ GI symptoms or history of GI disease. Ensure adequate fluid intake. Regularly check hepatic & renal function, & blood count. Avoid in concomitant use w/ other NSAIDs including COX-2 selective inhibitors. Not recommended w/ other therapy interfering haemostasia eg, warfarin or other coumarins or heparins. Combination therapy w/ protective agents eg, misoprostol or PPIs. Concomitant use w/ oral corticosteroids, anticoagulants eg, warfarin, SSRIs or anti-platelet agents eg, ASA. May affect ability to drive & use machines. Renal & hepatic impairment. May impair female fertility & not recommended in women attempting to conceive. Not to be given during 1st & 2nd trimester of pregnancy. Childn & adolescents. Elderly.