IV Administer as slow infusion over 30-60 min.
Adult & adolescent Maintenance dose: 9 MIU/day [300 mg of colistin base activity (CBA)] in 2-3 divided doses;
critically ill patient Administer loading dose of 9 MIU (300 mg of CBA).
Patient w/ CrCl <50-30 mL/min 5.5-7.5 MIU (183-250 mg of CBA) daily;
<30-10 mL/min 4.5-5.5 MIU (150-183 mg of CBA) daily;
<10 mL/min 3.5 MIU (116 mg of CBA) daily.
Patient in haemodialysis (HD) No-HD days: 2.25 MIU/day (75 mg of CBA) bid, 2.2-2.3 MIU/day (73-77 mg of CBA) bid; HD days: 3 MIU/day (100 mg of CBA) bid given after HD session.
Patient in continuous venovenous haemo(dia)filtration To be given tid.
Patient w/ totally implantable venous access device in place Bolus inj up to 2 MIU (68 mg of CBA) in 10 mL given over min of 5 min.
Childn weighing >40 kg Use adult dose,
<40 kg 75,000-150,000 IU/kg/day (2.5-5 mg of CBA) divided in 3 doses.
Childn w/ cystic fibrosis >150,000 IU/kg/day (5 mg of CBA).
Intrathecal/intraventricular Adult 125,000 (0.4 mg of CBA)/day via intraventricular route. Administer doses intrathecally not exceeding recommended intraventricular use.
Inhalation Adult, adolescent & childn ≥2 yr 1-2 MIU (34-68 mg of CBA) bid-tid [Max dose: 6 MIU/day (200 mg of CBA)].
Childn <2 yr 0.5-1 MIU (17-34 mg of CBA) bid [Max dose: 2 MIU/day (68 mg of CBA)].
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