Concise Prescribing Info
Per tab Co-trimoxazole: Trimethoprim 80 mg, sulfamethoxazole 400 mg. Per 5 mL syr Co-trimoxazole: Trimethoprim 40 mg, sulfamethoxazole 200 mg
Infections from gm +ve, gm -ve & other susceptible microorganism eg, resp tract, GIT, GUT & skin infections, septicemia.
Dosage/Direction for Use
Tab Adult 2 tab bid. Long-term treatment: 1 tab bid. Syr Childn >2 mth Usual dose: TMP 40 mg/kg/day to 1 mL (TMP 8 mg, SMX 40 mg)/kg/day divided to bid. 10 kg body wt 5 mL bid, 20 kg body wt 10 mL bid, 30 kg body wt 15 mL bid, 40 kg body wt 20 mL bid.
Should be taken with food.
Severely impaired hepatic or renal function; hypersensitivity to sulfonamides, blood dyscrasias. Pregnancy & lactation. Infant <2 mth. Porphyria.
Special Precautions
Patients w/ folic acid deficiency, poor nutritional states or G6PD deficiency. Elderly & patients w/ reduced kidney function.
Adverse Reactions
GI disturbances; Stevens-Johnson & Lyell's syndrome. Rarely, hepatitis, blood disorders, pseudomembranous colitis.
Drug Interactions
Effects reduced by PABA & procaine-type local anaesth & enhanced by highly-bound drugs. May potentiate effects of methotrexate, warfarin, sulfonylureas.
ATC Classification
J01EE01 - sulfamethoxazole and trimethoprim ; Belongs to the class of combinations of sulfonamides and trimethoprim, including derivatives. Used in the systemic treatment of infections.
Metrim syr
60 mL x 1's
Metrim tab
10 × 10's;500's
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