Myasthenia gravis. Discontinue treatment if hypersensitivity & allergic reactions occurs; psychiatric reactions. Prolonged QT interval. Patients w/ known prolongation of QTc interval, uncorrected hypokalemia, receiving class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmic agents. Concomitant use w/ drugs that prolong the QTc interval eg, cisapride, erythromycin, antipsychotics & TCAs; patients w/ ongoing proarrhythmic conditions eg, clinically significant bradycardia, acute myocardial ischemia; liver cirrhosis; women & elderly. Fulminant hepatitis; Stevens-Johnson syndrome or toxic epidermal necrolysis. CNS disorders. Initiate adequate therapeutic measures in patients who develop serious diarrhea; drug-induced inhibition of peristalsis are contraindicated. Tendon inflammation & rupture may occur in elderly patients & those treated concurrently w/ corticosteroids. Not recommended for patients w/ complicated pelvic inflammatory disease & for treatment of MRSA infections. May cause false negative results in Mycobacterium
spp culture test. Sensory or sensorimotor polyneuropathy resulting in paraesthesias, hypoaesthesias, dysaesthesias or weakness. Psychotic patients or w/ history of psychiatric disease. Avoid monotherapy treatment in patients w/ pelvic inflammatory disease. May impair ability to drive or operate machinery.