Prevention of thrombotic events (CV death, MI, stroke) in patients w/ a history of ST-elevation MI (STEMI), non-ST-elevation MI (NSTEMI), & unstable angina including patients managed medically & managed w/ percutaneous coronary intervention (PCI) or CABG.
Dosage/Direction for Use
Loading dose: 180 mg. Maintenance dose: 90 mg bid beginning about 12 hr after loading dose in the morning & evening for 1 yr after acute coronary syndrome event. Concomitant use w/ aspirin: Administer w/ a loading dose of aspirin 300-325 mg followed by a maintenance dose of aspirin 75-100 mg daily.
May be taken with or without food.
Hypersensitivity. History of intracranial hemorrhage, active bleeding, severe hepatic impairment.
Increased risk of bleeding. Contraindicated in patients w/ active pathological bleeding. Manage bleeding if possible w/o discontinuing treatment. If discontinuation of treatment is necessary, resume as soon as possible after bleeding source is identified & controlled. Avoid maintenance dose of aspirin >100 mg/day. Avoid initiating treatment if urgent CABG surgery is planned. Discontinue use at least 5 days prior to any surgery; discontinue in patients unable to tolerate treatment-related dyspnea. Ventricular pauses & bradyarrhythmias including AV block.