Adjunct to diet for reduction of elevated total cholesterol (total-C), LDL-C, Apo B, total-C: HDL-C ratio & triglycerides & for increasing HDL-C in hyper- & dyslipidemic conditions. Reduce total mortality & risk of major CV events in adults w/ increased risk of ASCVD based on presence of CV disease risk markers. Primary dysbetalipoproteinemia (type III hyperlipoproteinemia); primary hypercholesterolaemia [type IIa including heterozygous familial hypercholesterolaemia (HeFH) & severe non-familial hypercholesterolaemia]; combined (mixed) dyslipidemia (type IIb); HoFH. Adjunctive therapy to diet to slow progression of atherosclerosis in adults as part of treatment strategy to lower total-C & LDL-C to target levels. Adjunct to diet to reduce total-C, LDL-C & Apo B levels in adolescents at least 1 yr post-menarche, 10-17 yr w/ HeFH.