Alkeran愛克蘭

Alkeran

melphalan

Manufacturer:

Aspen Asia

Distributor:

Primal
Concise Prescribing Info
Contents
Melphalan
Indications/Uses
Dosage/Direction for Use
Tab Multiple myeloma 0.15 mg/kg body wt/day in divided doses for 4 days repeated at intervals of 6 wk. Advanced ovarian adenocarcinoma 0.2 mg/kg body wt/day for 5 days. Repeated 4-8 wkly or as soon as peripheral blood count has recovered. Breast carcinoma 0.15 mg/kg body wt daily or 6 mg/m2 BSA/day for 5 days & repeated 6 wkly. Polycythaemia rubra vera Remission induction: 6-10 mg daily for 5-7 days, then 2-4 mg daily until satisfactory disease control achieved. Maintenance: 2-6 mg once/wk. Inj Multiple myeloma 0.4 mg/kg body wt repeated at appropriate intervals. Ovarian adenocarcinoma 1 mg/kg body wt given at 4 wk intervals. Malignant melanoma Upper extremity perfusion: 0.6-1 mg/kg body wt. Lower extremity perfusion: 0.8-1.5 mg/kg body wt. Soft tissue sarcoma Upper extremity perfusion: 0.6-1 mg/kg body wt. Lower extremity perfusion: 1-1.4 mg/kg body wt. Advanced neuroblastoma 100-240 mg/m2 BSA.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals. Swallow whole, do not break/crush.
Contraindications
Pregnancy (1st trimester) & lactation.
Special Precautions
Immunisation using a live organism vaccine has the potential to cause infection in immunocompromised host. Monitor blood counts; should not be given to patients who have recently undergone radio- or chemotherapy. Renal impairment. Ensure adequate contraceptive precautions.
Adverse Reactions
Bone marrow depression, thrombocytopenia, anaemia; nausea, vomiting, diarrhea; stomatitis, alopecia, elevated blood urea; muscle atrophy & fibrosis, myalgia, increased blood creatinine phosphokinase, compartment syndrome; subjective & transient sensation of warmth &/or tingling.
Drug Interactions
Live organism vaccines, nalidixic acid, cyclosporin.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01AA03 - melphalan ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Alkeran film-coated tab 2 mg
Packing/Price
25's ($711/pack)
Form
Alkeran inj 50 mg
Packing/Price
1's ($3,224/vial)
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