Arcoxia安痛易

Arcoxia

etoricoxib

Manufacturer:

MSD

Distributor:

Zuellig
/
Agencia Lei Va Hong

Marketer:

A. Menarini
Concise Prescribing Info
Contents
Etoricoxib
Indications/Uses
Symptomatic relief of OA, RA, & ankylosing spondylitis. Treatment of acute gouty arthritis, & acute pain eg, primary dysmenorrhea. Short-term treatment of moderate pain associated w/ dental surgery.
Dosage/Direction for Use
OA 30 or 60 mg once daily. RA & ankylosing spondylitis 60 mg once daily. In patients w/ insufficient relief from symptoms, increase dose to 90 mg once daily. Once stabilised, titrate down to 60 mg once daily. Acute gouty arthritis & primary dysmenorrhea 120 mg once daily, to a max treatment of 8 days. Post-op dental surgery pain 90 mg once daily, to a max of 3 days. Hepatic insufficiency Mild: Max of 60 mg once daily. Moderate: Max of 60 mg every other day.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Active peptic ulceration or GI bleeding. Patients who experience bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria or allergic-type reactions after taking aspirin or NSAIDs including COX-2 inhibitors. Inflammatory bowel disease. CHF (NYHA II-IV). BP persistently >140/90 mmHg. Established ischemic heart disease, peripheral arterial disease &/or cerebrovascular disease. Treatment of peri-operative pain in the setting of CABG surgery. Severe hepatic dysfunction. Estimated renal CrCl <30 mL/min. Pregnancy & lactation. Chldn & adolescent <16 yr.
Special Precautions
Increased risk of serious GI adverse events. Risk of serious CV thrombotic events, MI, & stroke. Renal papillary necrosis & other renal injury in long-term administration; renal toxicity in patients whose renal prostaglandins have a compensatory role in the maintenance of renal perfusion. Risk of fluid retention, oedema & HTN. Control HTN before treatment. Elevations of ALT &/or AST. Discontinue treatment if signs of hepatic insufficiency occur, or if persistently abnormal liver function tests are detected. Patients w/ dehydration. Discontinue at the 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. May mask fever & other signs of inflammation. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Concomitant use w/ acetylsalicylic acid; warfarin or other oral anticoagulants. Women attempting to conceive. Elderly ≥65 yr.
Adverse Reactions
Abdominal pain. Alveolar osteitis; edema/fluid retention; dizziness, headache; palpitations, arrhythmia; HTN; bronchospasm; constipation, flatulence, gastritis, heartburn/acid reflux, diarrhea, dyspepsia/epigastric discomfort, nausea, vomiting, oesophagitis, oral ulcer; increased ALT, AST; ecchymosis; asthenia/fatigue, flu-like disease.
Drug Interactions
Increased prothrombin time w/ warfarin. Reduced effects of diuretics, ACE inhibitors & angiotensin II antagonists. Increased rate of GI ulceration w/ low-dose aspirin (used for CV prophylaxis). Increased nephrotoxic effects w/ cyclosporin or tacrolimus. Decreased renal excretion & increased plasma levels of lithium. Increased plasma conc & reduced renal clearance of methotrexate w/ 120 mg etoricoxib. Increased AUC of ethinyl estradiol, unconjugated estrone, equilin, estradiol. Decreased plasma conc w/ rifampin.
ATC Classification
M01AH05 - etoricoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.
Presentation/Packing
Form
Arcoxia tab 120 mg
Packing/Price
10's;30's
Form
Arcoxia tab 30 mg
Packing/Price
30's
Form
Arcoxia tab 60 mg
Packing/Price
30's
Form
Arcoxia tab 90 mg
Packing/Price
30's
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