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Boostrix

Boostrix

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig
Concise Prescribing Info
Contents
Diphtheria, tetanus & pertussis (acellular, component) vaccine (adsorbed, reduced antigen(s) content)
Indications/Uses
Booster vaccination against diphtheria, tetanus & pertussis for individuals from ≥4 yr. Passive protection against pertussis in early infancy following maternal immunisation during pregnancy.
Dosage/Direction for Use
Single 0.5 mL dose by deep IM inj, preferably in the deltoid region. Can be administered to pregnant women during the 2nd or 3rd trimester in accordance w/ official recommendations.
Contraindications
Hypersensitivity to any component of the vaccine, or after previous administration of DTP vaccines. Encephalopathy of unknown aetiology occurring w/in 7 days following previous vaccination w/ pertussis-containing vaccine. Transient thrombocytopenia or neurological complications following an earlier immunisation against diphtheria &/or tetanus.
Special Precautions
Postpone vaccination in subjects suffering from acute severe febrile illness. Do not administer intravascularly. Appropriate medical treatment & supervision should always be readily available in case of rare anaphylactic reactions following the administration of the vaccine. If any of the following occurs, the decision to give doses of pertussis-containing vaccine should be carefully considered: Temp ≥40°C w/in 48 hr, not due to another identifiable cause; collapse or shock-like state w/in 48 hr of vaccination; persistent, inconsolable crying lasting ≥3 hr, w/in 48 hr of vaccination; convulsions w/ or w/o fever, w/in 3 days of vaccination. Childn w/ new onset or progressive severe neurological disorders; individuals w/ thrombocytopenia or a bleeding disorder; immunosuppressed patients. Protective immune response may not be elicited in all vaccinees. Lactation.
Adverse Reactions
Pain, redness & swelling at inj site; headache; GI disorders; fatigue, pyrexia. Subjects 10-76 yr: Dizziness; nausea; malaise, inj site mass & abscess sterile. Subjects 4-8 yr: Anorexia; irritability; somnolence; diarrhoea, vomiting; extensive swelling of vaccinated limb.
Drug Interactions
May be administered concomitantly w/ HPV vaccine. Can be given concomitantly w/ meningococcal serogroups A, C, W-135 & Y (MenACWY) conjugate vaccines; unadjuvanted inactivated seasonal influenza vaccines; non-live herpes zoster vaccine. If to be given at the same time as other vaccines or Ig, the products should be given at separate sites. Response may not be adequately achieved if given w/ immunosuppressive therapy.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07AJ52 - pertussis, purified antigen, combinations with toxoids ; Belongs to the class of pertussis bacterial vaccines.
Presentation/Packing
Form
Boostrix vaccine (inj)
Packing/Price
(pre-filled syringe) 0.5 mL x 1's
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