TB, HTN, DM, osteoporosis, peptic ulcer (gastric or duodenal ulcer), glaucoma, cataract, family history of diabetes or glaucoma, or any other condition in which glucocorticosteroids may have undesirable effects. Risk of systemic effects of glucocorticosteroids when prescribed at high doses & for prolonged periods. Increased susceptibility to infections & their severity. Caution against chickenpox or shingles (herpes zoster) & measles especially in immunocompromised patients. Reports of visual disturbances w/ systemic & topical corticosteroid use. May cause suppression of HPA axis & reduce the stress response. Do not administer live vaccines to individuals w/ chronic glucocorticosteroid use. Ab response to other (inactivated) vaccines may be diminished. Avoid concomitant treatment w/ ketoconazole or other CYP3A inhibitors. Patients w/ severely impaired hepatic function. Pregnancy & lactation. Should not be used in childn & adolescents. Transfer from another glucocorticosteroid therapy may result in reappearance or recurrence symptoms relating to the change in systemic steroid levels. May cause local skin irritation due to cetyl alcohol & propylene glycol content.