Co-Diovan

Per 80/12.5 mg tab Valsartan 80 mg, hydrochlorothiazide 12.5 mg. Per 160/12.5 mg tab Valsartan 160 mg, hydrochlorothiazide 12.5 mg. Per 160/25 mg tab Valsartan 160 mg, hydrochlorothiazide 25 mg

HTN.

1 tab daily.

May be taken with or without food.

Hypersensitivity. Pregnancy, severe hepatic impairment, biliary cirrhosis & cholestasis, anuria, severe renal impairment (CrCl <30 mL/min), refractory hypokalaemia, hyponatraemia & hypercalcaemia symptomatic hyperuricaemia.

Na- &/or vol-depleted patients, renal artery stenosis, renal or hepatic impairment, SLE. Disturbance of serum electrolyte balance. Monitor serum K levels regularly. Concomitant use w/ drugs that may increase serum K levels. May affect ability to drive or operate machinery. Lactation.

Headache, dizziness, nasopharyngitis, fatigue, upper resp tract infection, cough, diarrhea, arthralgia, back pain.

Increased antihypertensive effect w/ other antihypertensive drugs. Concomitant use w/ K supplements, K-sparing diuretics, salt substitutes containing K, or other drugs that may alter K levels (heparin). Reversible increases in serum lithium conc & toxicity. Potentiated action of curare derivatives. Weaken diuretic & antihypertensive activity of thiazide w/ NSAIDs. Increased hypokalemic effect w/ kaliuretic diuretics, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G, salicylic acid derivatives. Increase hypersensitivity reactions to allopurinol; adverse effects by amantadine; enhanced hyperglycemic effect of diazoxide; reduced renal excretion of cytotoxic drugs (eg, cyclophosphamide, methotrexate). Increased bioavailability w/ anticholinergic agents (eg, atropine, biperiden). Hemolytic anemia may occur w/ methyldopa. Decreased absorption w/ cholestyramine. Potentiate rise in serum Ca w/ vit D or Ca salts. Increased risk of hyperuricemia & gout-type complications w/ cyclosporine. Hyponatremia may develop w/ carbamazepine.

Angiotensin II Antagonists / Diuretics

C09DA03 - valsartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.

P₁S₁S₃