Diflorasone


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% oint/cream: Apply a thin film onto the affected areas 1-4 times daily depending on the severity of the condition.
Contraindications
As treatment for rosacea or perioral dermatitis.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Significant: HPA axis suppression, manifestations of Cushing’s syndrome, hyperglycaemia, and glycosuria.
Dermatologic: Itching, burning, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration, atrophy, striae, miliaria, secondary infections.
Patient Counseling Information
Do not apply on the face, eyes, mucous membranes, intertriginous areas, occluded or broken skin, and into a large surface area.
MonitoringParameters
Monitor for hypothalamic-pituitary adrenal (HPA) axis suppression through ACTH stimulation test, plasma cortisol test, or urinary free cortisol test.
Action
Description: Diflorasone is a glucocorticoid that has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, hence depresses the formation, release, and activity of chemical inflammatory mediators.
Pharmacokinetics:
Absorption: Absorbed through normal intact skin (approx 1%); increased percutaneous absorption in inflamed or occluded skin.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Diflorasone, CID=71415, https://pubchem.ncbi.nlm.nih.gov/compound/Diflorasone (accessed on Jan. 21, 2020)

Storage
Store between 20-25°C.
ATC Classification
D07AC10 - diflorasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
References
Anon. Diflorasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/02/2017.

Buckingham R (ed). Diflorasone Diacetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/02/2017.

Diflorasone Diacetate Cream (E. Fougera & Co. A division of Fougera Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/02/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Dilforasone Diacetate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 16/02/2017.

Disclaimer: This information is independently developed by MIMS based on Diflorasone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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