Entigin肝敵清

Entigin

entecavir

Manufacturer:

Yung Shin

Distributor:

Yung Shin
Concise Prescribing Info
Contents
Entecavir
Indications/Uses
Chronic HBV infection in adults w/ evidence of active viral replication.
Dosage/Direction for Use
Nucleoside-treatment naïve adult & adolescent ≥16 yr 0.5 mg once daily. Adult & adolescent ≥16 yr w/ history of hepatitis B viremia while receiving lamivudine or known lamivudine resistance mutations 1 mg once daily. Patient w/ renal impairment CrCl ≥50 mL/min Usual dose: 0.5 mg once daily. Lamivudine-refractory: 1 mg once daily, CrCl 30 to <50 mL/min Usual dose: 0.5 mg every 48 hr. Lamivudine-refractory: 0.5 mg once daily or 1 mg every 48 hr, CrCl 10 to <30 mL/min Usual dose: 0.5 mg every 72 hr. Lamivudine-refractory: 1 mg every 72 hr, CrCl <10 mL/min or patient on hemodialysis or continuous ambulatory peritoneal dialysis Usual dose: 0.5 mg every 7 days. Lamivudine-refractory dose: 1 mg every 7 days.
Administration
Should be taken on an empty stomach: Take at least 2 hr before & after a meal.
Contraindications
Special Precautions
Severe acute exacerbations of hepatitis B in patients who have discontinued anti-hepatitis B therapy; closely monitor hepatic function for at least several mth after discontinuation. Not recommended for HIV/HBV co-infected patients who are not also receiving highly active antiretroviral therapy. Perform HIV Ab testing before initiating therapy. Not recommended as HIV treatment. Lactic acidosis & severe hepatomegaly w/ steatosis, including fatal cases, w/ the use of nucleoside analogues alone or in combination w/ antiretrovirals. Patients w/ renal impairment. Pregnancy & lactation. Ped patients <16 yr. Elderly.
Adverse Reactions
Headache, fatigue, dizziness, & nausea.
Drug Interactions
Co-administration of entecavir w/ drugs that reduce renal function or compete for active tubular secretion may increase serum conc of either entecavir or the co-administered drug.
MIMS Class
Antivirals
ATC Classification
J05AF10 - entecavir ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Entigin tab 0.5 mg
Packing/Price
2 × 14's
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