Not recommended for use in patients receiving loop diuretics or vol depleted eg, due to acute illness (eg, GI illness). Exercise caution in patients w/ known CV disease, patients on antihypertensive therapy w/ history of hypotension or elderly. Reports of acute kidney injury; elevated haematocrit; diabetic ketoacidosis; necrotising fasciitis of the perineum (Fournier's gangrene); UTI eg, pyelonephritis or urosepsis. Should not be used for treatment of patients w/ type 1 diabetes. Patients w/ cardiac failure. Increased cases of lower limb amputations in ongoing long-term, clinical studies w/ another SGLT2 inhibitor. Not recommended for concomitant use w/ pioglitazone. Tests positive for glucose in urine. Monitoring glycaemic control w/ 1,5-AG assay is not recommended. Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption. Should not be initiated in patients w/ GFR <60 mL/min. Discontinue in patients w/ GFR persistently below 45 mL/min. Hepatic impairment. Not recommended during 2nd & 3rd trimesters of pregnancy. Lactation. Elderly ≥65 yr. Childn <18 yr.