Glypressin

Glypressin

terlipressin

Manufacturer:

Ferring

Distributor:

DCH Auriga - Universal
/
Four Star
Concise Prescribing Info
Contents
Terlipressin
Indications/Uses
Treatment of bleeding oesophageal varices. Emergency treatment of type 1 hepatorenal syndrome as defined by International Ascites Club (IAC) criteria.
Dosage/Direction for Use
Adult Bleeding oesophageal varices Initially 2 mg IV every 4 hr. It should be maintained until bleeding has been controlled for 24 hr up to a max of 48 hr. <50 kg or if adverse effects occur After initial dose, adjust dose to 1 mg IV every 4 hr. Type 1 hepatorenal syndrome 3-4 mg given every 24 hr as 3-4 administrations. Continue until obtaining either of a serum creatinine <130 micromol/L or of a drop of at least 30% in the serum creatinine w/ respect to the value measured at the time of diagnosis of hepatorenal syndrome. Standard ave duration of treatment: 10 days.
Contraindications
Pregnancy, hypersensitivity.
Special Precautions
Monitor BP, heart rate & fluid balance during treatment. Patient w/ HTN, recognised heart disease, renal dysfunction, cerebral or peripheral vascular disease, asthma or resp failure. Do not use in patient w/ septic shock w/ low cardiac output. Administer IV to avoid local necrosis at the inj site. Lactation. Childn. Elderly.
Adverse Reactions
Common: Headache, bradycardia, peripheral vasoconstriction, peripheral ischemia, facial pallor, HTN, transient abdominal cramps, transient diarrhoea. Uncommon: Hyponatraemia (if fluid not monitored), atrial fibrillation, ventricular extrasystoles, tachycardia, chest pain, MI, fluid overload w/ pulmonary oedema, Torsade de pointes, cardiac failure, intestinal ischaemia, peripheral cyanosis, hot flushes, resp distress/failure, transient nausea & vomiting, inj site necrosis, uterine hypertonus, uterine ischemia.
Drug Interactions
Increased hypotensive effects of non-selective β-blockers. Concomitant use w/ propofol & sufentanil may lower heart rate & cardiac output.
MIMS Class
ATC Classification
H01BA04 - terlipressin ; Belongs to the class of vasopressin and analogues. Used in posterior pituitary lobe hormone preparations.
Presentation/Packing
Form
Glypressin soln for inj 1 mg/8.5 mL
Packing/Price
5's
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