Treatment of moderate to severe infections caused by susceptible strains of microorganisms as well as initial empiric therapy prior to identification of causative organisms in complicated intra-abdominal infections; complicated skin & skin structure infections, including diabetic foot infections w/o osteomyelitis; community acquired pneumonia; complicated UTI including pyelonephritis; acute pelvic infections, including postpartum endomyometritis, septic abortion & post surgical gynecologic infections. Prophylaxis of surgical site infection following elective colorectal surgery in adults.
IV infusion/IM injAdult & childn ≥13 yr 1 g once daily. 3 mth-12 yr 15 mg/kg bd, max 1 g/day. IV should be infused over 30 min. Duration of therapy: 3-14 days. Prophylaxis of surgical site infection following elective colorectal surgeryAdult 1 g IV 1 hr pre-op. Advanced renal insufficiency (CrCl ≤30 mL/min/1.73 m2) 500 mg daily. Haemodialysis 500 mg w/in 6 hr prior to haemodialysis, & a supplementary dose of 150 mg following haemodialysis.
History of sensitivity to penicillins, cephalosporins, other β-lactams & other allergens. Discontinue if allergic reaction occurs. Patients w/ CNS disorders (eg, brain lesions or history of seizures) &/or compromised renal function. May result in overgrowth of non-susceptible organisms upon prolonged use. Reports of pseudomembranous colitis. Use cautiously when administered IM. Concomitant use w/ valproic acid/divalproex Na. Lidocaine HCl is the diluent for IM administration. Pregnancy & lactation. Not recommended in infant <3 mth.