Agencia Lei Va Hong
Concise Prescribing Info
Treatment of moderate to severe infections caused by susceptible strains of microorganisms as well as initial empiric therapy prior to identification of causative organisms in complicated intra-abdominal infections; complicated skin & skin structure infections, including diabetic foot infections w/o osteomyelitis; community acquired pneumonia; complicated UTI including pyelonephritis; acute pelvic infections, including postpartum endomyometritis, septic abortion & post surgical gynecologic infections. Prophylaxis of surgical site infection following elective colorectal surgery in adults.
Dosage/Direction for Use
IV infusion/IM inj Adult & childn ≥13 yr 1 g once daily. 3 mth-12 yr 15 mg/kg bd, max 1 g/day. IV should be infused over 30 min. Duration of therapy: 3-14 days. Prophylaxis of surgical site infection following elective colorectal surgery Adult 1 g IV 1 hr pre-op. Advanced renal insufficiency (CrCl ≤30 mL/min/1.73 m2) 500 mg daily. Haemodialysis 500 mg w/in 6 hr prior to haemodialysis, & a supplementary dose of 150 mg following haemodialysis.
Hypersensitivity to ertapenem & other β-lactams. IM: Hypersensitivity to lidocaine or amide-type local anaesth. Severe shock or heart block.
Special Precautions
History of sensitivity to penicillins, cephalosporins, other β-lactams & other allergens. Discontinue if allergic reaction occurs. Patients w/ CNS disorders (eg, brain lesions or history of seizures) &/or compromised renal function. May result in overgrowth of non-susceptible organisms upon prolonged use. Reports of pseudomembranous colitis. Use cautiously when administered IM. Concomitant use w/ valproic acid/divalproex Na. Lidocaine HCl is the diluent for IM administration. Pregnancy & lactation. Not recommended in infant <3 mth.
Adverse Reactions
Headache; infused vein complication, phlebitis/thrombophlebitis; diarrhea, nausea, vomiting; infusion site erythema, pain & swelling; rash.
Drug Interactions
Inhibited renal excretion w/ probenecid. Reduced conc of valproic acid causing increased risk of breakthrough seizures.
MIMS Class
ATC Classification
J01DH03 - ertapenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.
Invanz powd for inj 1 g
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