Invanz

Invanz

ertapenem

Manufacturer:

MSD

Distributor:

Zuellig
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Ertapenem
Indications/Uses
Treatment of moderate to severe infections caused by susceptible strains of microorganisms as well as initial empiric therapy prior to identification of causative organisms in complicated intra-abdominal infections; complicated skin & skin structure infections, including diabetic foot infections w/o osteomyelitis; community acquired pneumonia; complicated UTI including pyelonephritis; acute pelvic infections, including postpartum endomyometritis, septic abortion & post surgical gynecologic infections. Prophylaxis of surgical site infection following elective colorectal surgery in adults.
Dosage/Direction for Use
IV infusion/IM inj Adult & childn ≥13 yr 1 g once daily. 3 mth-12 yr 15 mg/kg bd, max 1 g/day. IV should be infused over 30 min. Duration of therapy: 3-14 days. Prophylaxis of surgical site infection following elective colorectal surgery Adult 1 g IV 1 hr pre-op. Advanced renal insufficiency (CrCl ≤30 mL/min/1.73 m2) 500 mg daily. Haemodialysis 500 mg w/in 6 hr prior to haemodialysis, & a supplementary dose of 150 mg following haemodialysis.
Contraindications
Hypersensitivity to ertapenem & other β-lactams. IM: Hypersensitivity to lidocaine or amide-type local anaesth. Severe shock or heart block.
Special Precautions
History of sensitivity to penicillins, cephalosporins, other β-lactams & other allergens. Discontinue if allergic reaction occurs. Patients w/ CNS disorders (eg, brain lesions or history of seizures) &/or compromised renal function. May result in overgrowth of non-susceptible organisms upon prolonged use. Reports of pseudomembranous colitis. Use cautiously when administered IM. Concomitant use w/ valproic acid/divalproex Na. Lidocaine HCl is the diluent for IM administration. Pregnancy & lactation. Not recommended in infant <3 mth.
Adverse Reactions
Headache; infused vein complication, phlebitis/thrombophlebitis; diarrhea, nausea, vomiting; infusion site erythema, pain & swelling; rash.
Drug Interactions
Inhibited renal excretion w/ probenecid. Reduced conc of valproic acid causing increased risk of breakthrough seizures.
MIMS Class
ATC Classification
J01DH03 - ertapenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.
Presentation/Packing
Form
Invanz powd for inj 1 g
Packing/Price
1's
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