Periodically perform LFTs, kidney function tests and blood cell counts during prolonged therapy.
May potentiate effects of neuromuscular blocking agents (e.g. pancuronium, tubocurarine). Reduced GI absorption w/ kaolin. May antagonise the effect of erythromycin.
Food reduces the rate and extent of absorption.
Description: Lincomycin exerts bacteriostatic and bactericidal effects by binding to 50S ribosome subunit. This results in inhibition of protein synthesis, specifically peptide-bond formation, in susceptible organisms. Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract (approx 20-35%). Time to peak plasma concentration: W/in 2-4 hr. Food reduces rate and extent of absorption. Distribution: Widely distributed into tissues including bone and body fluids; poor diffusion into the CSF. Crosses the placenta and enters breast milk. Metabolism: Partially metabolised in the liver. Excretion: Via bile, urine, faeces (as unchanged drug and metabolites). Plasma half-life: Approx 5 hr.
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