NESP

NESP

darbepoetin alfa

Manufacturer:

Kyowa Kirin

Distributor:

DCH Auriga - Healthcare
/
Four Star
Concise Prescribing Info
Contents
Darbepoetin α
Dosage/Direction for Use
IV Hemodialysis patient Initial dose: 20 mcg single inj once wkly. When switching from erythropoietin prep: Initially 15-60 mcg single inj once wkly. Maintenance dose: 15-60 mcg single inj once wkly. If alleviation of anemia is maintained by once wkly inj, dose can be changed to 2-fold of the initial dose, administered once every 2 wk. Max: 180 mcg single inj. SC/IV Peritoneal dialysis patient & patient w/ chronic kidney disease (CKD) not on dialysis Initial dose: 30 mcg single inj once every 2 wk. When switching from erythropoietin prep: Initially 30-120 mcg single inj once every 2 wk. Maintenance dose: 30-120 mcg single inj once every 2 wk. If alleviation of anemia is maintained by once every 2 wk inj, dose can be changed to 2-fold of the initial dose, administered once every 4 wk. Max: 180 mcg single inj.
Contraindications
Special Precautions
Start therapy when Hb conc is <10-11 g/dL. Confirm diagnosis of renal anemia. Assess risk of shock. Monitor Hb conc, hematocrit level, BP at regular intervals. Monitor fluid & electrolyte balance & renal function at regular intervals for patient w/ CKD not on dialysis. Administer Fe w/ Fe deficiency. Concomitant use w/ erythropoiesis-stimulating agents. Patients w/ history of hypersensitivity; allergic predisposition; myocardial/pulmonary/cerebral infarction or those w/ history of these conditions who may experience thromboembolism; HTN. Hypertensive encephalopathy; pure red cell aplasia; hyperkalaemia; shunt occlusion or residual blood in hemodialyzers; blistering & skin exfoliation reactions. Pregnancy & lactation. Childn. Elderly.
Adverse Reactions
Cerebral infarction &/or hemorrhage; hepatic function disorder &/or jaundice; hypertensive encephalopathy; shock & anaphylactoid reactions; pure red cell aplasia; myocardial &/or pulmonary infarction.
ATC Classification
B03XA02 - darbepoetin alfa ; Belongs to the class of other antianemic preparations. Used in the treatment of anemia.
Presentation/Packing
Form
NESP inj 120 mcg/0.5 mL
Packing/Price
1's
Form
NESP inj 180 mcg/0.5 mL
Packing/Price
1's
Form
NESP inj 20 mcg/0.5 mL
Packing/Price
1's
Form
NESP inj 40 mcg/0.5 mL
Packing/Price
1's
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