glyceryl trinitrate


G Pohl-Boskamp


HK Medical Supplies
Health Express
Concise Prescribing Info
Treatment of all forms of episodic cardiac pain (arrestation of angina pectoris attacks). Prophylaxis of angina pectoris. Acute cardiac infarction. Acute myocardial insufficiency, w/ acutely impaired left ventricular function. Catheter-induced coronary spasms during coronary angiography.
Dosage/Direction for Use
1-2 puffs (0.4-0.8 mg), as required. Acute left heart failure or acute cardiac infarction 1-3 puffs (0.4-1.2 mg), as required.
Hypersensitivity. Acute circulatory failure; severe hypotension; cardiogenic shock, unless a sufficiently high left ventricular end-diastolic pressure is assured by intra-aortal counterpulsation or positive inotropic drugs; myocardial diseases concerning reduced cardiac vol; constructive pericarditis; pericardial tamponade; primary pulmonary HTN. Concomitant use w/ certain drugs for erectile dysfunction or pulmonary arterial HTN.
Special Precautions
Careful medical supervision in patients w/ acute cardiac infarction w/ low filling pressures; aortic &/or mitral stenosis; orthostatic disturbances of circulatory regulation; diseases associated w/ increased intracranial pressure. Tolerance development & occurrence of cross tolerance to other nitro compounds. Attenuation of the haemodynamic effects w/in 24 hr. May impair ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Headache; decline in BP, orthostatic hypotension.
Drug Interactions
Potentiated antihypertensive effect w/ other vasodilators, antihypertensives, β-blockers, Ca antagonists, neuroleptics or TCAs, alcohol. Enhanced hypotensive effect w/ certain drugs (phosphodiesterase inhibitors) for erectile dysfunction or pulmonary arterial HTN. Patients previously treated w/ organic nitrates (eg, isosorbide dinitrate, isosorbide-5-mononitrate) may require increase in glyceryl trinitrate dose to achieve desired effect. Enhanced hypertensive effect of dihydroergotamine. Weakened effect of heparin.
MIMS Class
ATC Classification
C01DA02 - glyceryl trinitrate ; Belongs to the class of organic nitrate vasodilators. Used in the treatment of cardiac disease.
Nitrolingual aerosol spray 0.4 mg/dose
(12.2 mL bottle) 200 dose x 1's
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