pms-Baclofen Description





Full Prescribing Info
Each tablet contains 10 mg of baclofen.
Proper Name: Baclofen.
Chemical Names: (i) 4-Amino-3-(p-chlorophenyl) butyric acid; (ii) β-(Aminomethyl)-4-chlorobenzenepropionic acid; (iii) β-(Aminomethyl)-p-chlorohydrocinnamic acid; (iv) τ-Amino-β-(p-chlorophenyl)butyric acid; (v) β-(4-Chlorophenyl) GABA.
Molecular Mass: 213.66 g/mol.
Molecular Formula: C10H12ClNO2.
Physicochemical Properties: Description: Baclofen is a white to off-white, virtually odourless, crystalline powder with a slightly bitter taste.
Melting Point: The melting range (192°C-193°C) of baclofen can vary due to lactam formation with a concomitant loss of water.
Solubility: Baclofen is slightly soluble in water, poorly soluble in organic solvents.
pKa: The pKa values in water (5.0 x 10-3 moles/l) at 20°C are as follows: pKa1 = 3.87 + 0.1 (carboxyl group); pKa2 = 9.62 + 0.1 (amino group).
Excipients/Inactive Ingredients: Colloidal Silicon Dioxide, Dibasic Calcium Phosphate, Lactose Anhydrous, Magnesium Stearate, Microcrystalline Cellulose, and Sodium Starch Glycolate.
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