pms-Gabapentin

pms-Gabapentin

gabapentin

Manufacturer:

Pharmascience

Distributor:

T-BOMA
Concise Prescribing Info
Contents
Gabapentin
Indications/Uses
Adjunctive therapy for the management of patients w/ epilepsy who are not satisfactorily controlled by conventional therapy.
Dosage/Direction for Use
Adult Initially 300 mg tds, may be increased to max 1,800 mg/day. Doses up to 3,600 mg/day have been well tolerated. Daily maintenance dose: Should be given in 3 equally divided doses w/ max interval of 12 hr between doses. Patient w/ renal impairment, CrCl >30-59 mL/min 400-1,400 mg/day in 2 divided doses administered bd, CrCl >15-29 mL/min 200-700 mg once daily, CrCl 15 mL/min 100-300 mg once daily. Patient on hemodialysis 125-350 mg/day post-hemodialysis supplemental dose administered after each 4 hr of hemodialysis.
Administration
May be taken with or without food: Swallow whole w/ sufficient fluid.
Special Precautions
Not effective in the treatment of absence seizures; caution in patients who have mixed seizure disorders that include absence seizures. Possibility of increased seizure frequency w/ abrupt w/drawal. Associated w/ dizziness & somnolence; CNS depression as well as serious cases of resp depression. May result in life-threatening resp depression when concomitantly used w/ opioids. May cause psychomotor impairment. Can cause anaphylaxis. Discontinue in case of hypersensitivity reactions or signs & symptoms suggestive of Stevens-Johnson syndrome, erythema multiforme, drug rash w/ eosinophilia & systemic symptoms (DRESS). Monitor patients for signs of suicidal ideation & behaviour. Patients w/ history of drug abuse. For urinary protein determination, sulfosalicylic acid precipitation procedure is recommended. Patients w/ renal impairment. May cause fetal harm. Pregnancy & lactation. Ped patients <18 yr. Elderly >65 yr.
Adverse Reactions
Somnolence, dizziness, ataxia, fatigue, nystagmus, tremor.
Drug Interactions
Not recommended w/ co-administration of Al- & Mg-based antacids. Additive effect on impairment of cognitive & gross motor function w/ opioids, benzodiazepines, alcohol. Resp failure, coma, death w/ other CNS depressants, including in patients w/ substance use disorders.
MIMS Class
Anticonvulsants
ATC Classification
N03AX12 - gabapentin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
pms-Gabapentin cap 100 mg
Packing/Price
100's
Form
pms-Gabapentin cap 300 mg
Packing/Price
100 × 10's;100's;3 × 10's;50 × 10's;500's
Form
pms-Gabapentin cap 400 mg
Packing/Price
100 × 10's;100's;3 × 10's;50 × 10's
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