Initially 300 mg tds, may be increased to max 1,800 mg/day. Doses up to 3,600 mg/day have been well tolerated. Daily maintenance dose: Should be given in 3 equally divided doses w/ max interval of 12 hr between doses. Patient w/ renal impairment, CrCl >30-59 mL/min
400-1,400 mg/day in 2 divided doses administered bd, CrCl >15-29 mL/min
200-700 mg once daily, CrCl 15 mL/min
100-300 mg once daily. Patient on hemodialysis
125-350 mg/day post-hemodialysis supplemental dose administered after each 4 hr of hemodialysis.