pms-Trazodone Description





Full Prescribing Info
Each tablet contains trazodone hydrochloride 50 mg or 100 mg respectively equivalent to 45.5 mg and 91 mg trazodone base.
Proper name: Trazodone Hydrochloride.
Chemical name: 2-{3-[4-(3-chlorophenyl)-1-piperazinyl]propyl}-1,2,4-triazolo-[4,3-a]pyridin-3(2H)-one monohydrochloride.
Molecular formula: C19H22ClN5O·HCl.
Molecular mass: 408.32 g/mol.
Physicochemical properties: White, odorless crystals (plates) with a bitter taste. The melting point for trazodone free base is 96°C. The hydrochloride salt melts with decomposition in the range 222-228°C. Under vacuum decomposition does not occur and a melting range of 231-232.5°C is reported. Trazodone Hydrochloride is sparingly soluble in chloroform and in water. The reported pKa for trazodone in 50% ethanol is 6.14. This value was obtained potentiometrically using a glass-calomel electrode.
Excipients/Inactive Ingredients: croscarmellose sodium, dibasic calcium phosphate, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch.
50 mg: FD&C Yellow #6.
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