Agencia Lei Va Hong
Concise Prescribing Info
Per 0.5 mL dose Measles virus Enders' Edmonston strain (live, attenuated) not less than 3 log10 TCID50, mumps virus Jeryl Lynn (level B) strain (live, attenuated) not less than 4.3 log10 TCID50, rubella virus Wistar RA 27/3 strain (live, attenuated) not less than 3 log10 TCID50, varicella virus Oka/Merck strain (live, attenuated) not less than 3.99 log10 PFU
Simultaneous vaccination against measles, mumps, rubella, & varicella in individuals from 12 mth of age. Can be administered to individuals from 9 mth of age under special circumstances.
Dosage/Direction for Use
IM/SC Childn ≥12 mth 2 doses of ProQuad or a single dose followed by a 2nd dose of monovalent varicella vaccine. Administer 2nd dose preferrably w/in 3 mth following the 1st dose, 9-12 mth Administer 2nd dose of ProQuad after a min interval of 3 mth following the 1st dose. At least 1 mth must elapse between the 1st & 2nd dose of any live viral attenuated vaccine.
History of hypersensitivity to any varicella vaccine or measles, mumps, or rubella vaccine, or to neomycin. Blood dyscrasias, leukaemia, lymphomas of any type, or other malignant neoplasms affecting the haematopoietic & lymphatic system. Current immunosuppressive therapy (including high doses of corticosteroids). Severe humoral or cellular (primary or acquired) immunodeficiency. Severely immunocompromised individuals. Family history of congenital or hereditary immunodeficiency. Active untreated TB. Postpone vaccination during any illness w/ fever >38.5°C. Pregnancy. Avoid pregnancy for 1 mth following vaccination.
Special Precautions
History of anaphylactic, anaphylactoid, or other immediate reactions subsequent to egg ingestion. Individual or family history of convulsions, or a history of cerebral injury. Be alert to temp elevation that may occur following vaccination. Potential transmission of live attenuated rubella virus & varicella vaccine virus. Risk of thrombocytopenia; febrile seizures. Carefully monitor immunocompromised patients who have no contraindication for this vaccination for signs of measles, parotitis, rubella & varicella. Temporary depression of tuberculin skin sensitivity. Fructose intolerance. Women of childbearing potential should delay pregnancy. Lactation. Infants <12 mth may fail to respond to vaccine. Not indicated in infants <9 mth.
Adverse Reactions
Inj site reactions including pain/tenderness/soreness, redness, swelling or bruising; fever (≥39.4°C rectal equivalent). Irritability; rash (including measles-like rash, varicella-like rash, & inj site rash); upper resp infection; vomiting & diarrhoea.
Drug Interactions
At least 1 mth should elapse between receipt of any live virus vaccine & ProQuad. Avoid use of salicylates for 6 wk after vaccination. Reduced immune response w/ Ig (eg, varicella zoster immune globulin).
ATC Classification
J07BD54 - measles, combinations with mumps, rubella and varicella, live attenuated ; Belongs to the class of measles vaccines.
ProQuad powd & solvent for susp for vaccine inj
(0.75 mL of sterile diluent + 1 dose vial) 10 × 1's; (0.75 mL of sterile diluent + 1 dose vial) 1's
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