Romiplate

Romiplate

romiplostim

Manufacturer:

Kyowa Kirin

Distributor:

DCH Auriga - Healthcare
/
Four Star
Concise Prescribing Info
Contents
Romiplostim
Indications/Uses
Chronic immune (idiopathic) thrombocytopenic purpura in splenectomised patients who are refractory to corticosteroids & immunoglobulins. 2nd-line treatment for non-splenectomised patients where surgery is contraindicated.
Dosage/Direction for Use
SC inj Initially 1 mcg/kg body wt once wkly, may increased by increments of 1 mcg/kg body wt. Max: 10 mcg/kg body wt once wkly.
Contraindications
Hypersensitivity to romiplostim, E. coli-derived proteins.
Special Precautions
Recurrence of thrombocytopenia & bleeding on discontinuation. Increased bone marrow reticulin. Thrombotic/thromboembolic complications. Progression of existing haematopoietic malignancies or myelodysplastic syndrome. Immunogenicity. Alterations in RBC & WBC. Renal & hepatic impairment. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Headache, bone marrow disorder, thrombocytopenia, insomnia, dizziness, paraesthesia, migraine, flushing, pulmonary embolism, GI disturbances, pruritus, ecchymosis, rash, arthralgia, myalgia, pain in extremity, muscle spasm, bone & back pain, fatigue, inj site reactions (including pain, haematoma & swelling), peripheral oedema, asthenia, pyrexia, chills, contusion.
MIMS Class
ATC Classification
B02BX04 - romiplostim ; Belongs to the class of other systemic hemostatics. Used in the treatment of hemorrhage.
Presentation/Packing
Form
Romiplate powd for soln for inj 250 mcg
Packing/Price
1's
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