Increased risk of hypoglycemia w/ antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (eg, octreotide), & sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. Decreased blood glucose lowering effect w/ atypical antipsychotics (eg, olanzapine & clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, OCs, phenothiazines, progestogens (eg, in OCs), PIs, somatropin, sympathomimetic agents (eg, albuterol, epinephrine, terbutaline), & thyroid hormones. Possible increased or decreased blood glucose lowering effect w/ alcohol, β-blockers, clonidine, & lithium salts. Pentamidine may cause hypoglycemia, which may sometimes be followed by hyperglycemia. Blunted signs & symptoms of hypoglycemia w/ β-blockers, clonidine, guanethidine, & reserpine.