Agencia Lei Va Hong
Concise Prescribing Info
Salbutamol sulfate
Nebules Routine management of chronic bronchospasm unresponsive to conventional therapy. Treatment of acute severe asthma (status asthmaticus). Accuhaler/inhaler Relief & prevention of asthma symptoms. Relief medication in mild, moderate or severe asthma. IV infusion Relief of severe bronchospasm associated w/ asthma or bronchitis & treatment of status asthmaticus. Short-term management of uncomplicated premature labour; to arrest labour between 22 & 37 wk of gestation.
Dosage/Direction for Use
Nebules Adult & childn 2.5-5 mg, may be repeated qds via a nebuliser. Severe airway obstruction (high adult dose): up to 40 mg/day under strict medical supervision in hospital. Accuhaler Adult (including the elderly) Relief of acute bronchospasm 200 mcg as a single dose. Max: 200 mcg qds. Prevention of allergen- or exercise-induced asthma 200 mcg 10-15 min before challenge. Childn Relief of acute bronchospasm or before allergen exposure or exercise 200 mcg. Max: 200 mcg qds. Inhaler Adult (including the elderly) & childn Relief of acute asthma symptoms including bronchospasm 1 inhalation (100 mcg) as a single minimum starting dose, may be increased to 2 if necessary. Prevention of allergen- or exercise-induced symptoms Adult (including the elderly) 2 inhalations 10-15 min before challenge. Childn 1 inhalation, or 2 if necessary. Chronic therapy 2 inhalations up to qds. Should not exceed 8 inhalations in any 24 hr. Infusion Adult & childn ≥12 yr Severe bronchospasm & status asthmaticus 3-20 mcg/min. Resp failure Increase dose. Uncomplicated premature labour Dose must be individually titrated. Infusion rates of 10-45 mcg/min are generally adequate. Initially 10 mcg/min, increasing at 10-min interval until patient response. Thereafter, infusion rate may be increased slowly until contractions cease. Once contractions have ceased, maintain infusion rate at the same level for 1 hr & then reduce by 50% decrements at 6-hrly intervals.
Hypersensitivity to any of the components. Non-IV formulations must not be used to arrest uncomplicated premature labour or threatened abortion. Accuhaler Patients w/ severe milk-protein allergy. IV infusion Any condition at a gestational age <22 wk. Ischaemic heart disease. Threatened abortion during 1st & 2nd trimester. Any condition of the mother or foetus in which prolongation of the pregnancy is hazardous. Intrauterine foetal death. Pre-existing medical conditions w/ which a betamimetic would have an untoward effect eg, pulmonary HTN & cardiac disorders eg, hypertrophic obstructive cardiomyopathy or any type of obstruction of the left ventricular outflow tract eg, aortic stenosis.
Special Precautions
Reassess therapy plan in case of deterioration of asthma control. Patients w/ thyrotoxicosis. Concomitant treatment w/ xanthine derivatives, steroids, diuretics; hypoxia. Monitor serum K levels. Pregnancy & lactation. Nebule Patients known to have received large doses of other sympathomimetic drugs. Acute angle closure glaucoma w/ nebulized ipratropium Br. IV Reports of maternal pulmonary oedema & myocardial ischaemia. Discontinue treatment if signs of myocardial ischaemia develop. Should not be used as a tocolytic agent in patients w/ significant risk factors for, or a suspicion of any kind of pre-existing heart disease. Monitor maternal pulse rate. Nebule/IV Reversible metabolic changes eg, reversible hypokalaemia & increased blood sugar levels. Lactic acidosis. Nebule/Accuhaler/Inhaler Paradoxical bronchospasm.
Adverse Reactions
Tremor, headache, tachycardia, hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension & collapse, hypokalaemia, hyperactivity, palpitations, cardiac arrhythmias including atrial fibrillation, supraventricular tachycardia & extrasystoles, peripheral vasodilatation, muscle cramps. Accuhaler, inhaler & IV: Myocardial ischaemia. Nebule, inhaler & accuhaler: Paradoxical bronchospasm, mouth & throat irritation. Nebule & IV: Lactic acidosis. IV: Hyperglycaemia, decrease in diastolic pressure, hypotension, pulmonary oedema, nausea, vomiting.
Drug Interactions
Inhaled prep: Concomitant administration w/ non-selective β-blocking drugs eg, propranolol. IV prep: Concomitant administration w/ non-selective β-blocking drugs eg, propranolol, halogenated anaesthetics, corticosteroids, anti-diabetics, K-depleting agents.
ATC Classification
R03AC02 - salbutamol ; Belongs to the class of adrenergic inhalants, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
R03CC02 - salbutamol ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
Inhaler: P1; Accuhaler, Soln for IV infusion (amp), Nebules: P1S1S3
Ventolin accuhaler 200 mcg/actuation
60 actuation x 1's
Ventolin nebules 2.5 mg/2.5 mL
20 × 1's
Ventolin infusion 5 mg/5 mL
10 × 1's
Ventolin inhaler 100 mcg/actuation
(CFC-free) 200 actuation x 1's
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