Verzenio

Verzenio

abemaciclib

Manufacturer:

Eli Lilly

Distributor:

Zuellig
Concise Prescribing Info
Contents
Abemaciclib
Indications/Uses
Treatment of women w/ hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative locally advanced or metastatic breast cancer in combination w/ an aromatase inhibitor or fulvestrant as initial endocrine-based therapy, or in women who have received prior endocrine therapy.
Dosage/Direction for Use
150 mg bd, in combination w/ endocrine therapy.
Administration
May be taken with or without food: Take at the same time each day. Swallow whole, do not chew/crush/split. Avoid grapefruit or grapefruit juice.
Contraindications
Special Precautions
Risk of neutropenia; infections; venous thromboembolic events; increases in ALT & AST; diarrhoea. Avoid concomitant use w/ CYP3A4 inducers. Patients w/ visceral crisis. Rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Minor influence on the ability to drive & use machines. Severe renal or hepatic impairment. Women of childbearing potential should use highly effective contraception methods (eg, double-barrier contraception) during treatment & for at least 3 wk after completing therapy. Not recommended during pregnancy & in women of child-bearing potential not using contraception. Lactation. Childn <18 yr.
Adverse Reactions
Diarrhoea, infections, neutropenia, anaemia, fatigue, nausea, vomiting, decreased appetite.
Drug Interactions
Increased plasma conc w/ strong CYP3A4 inhibitors (eg, clarithromycin, itraconazole, ketoconazole, lopinavir/ritonavir, posaconazole or voriconazole). Avoid grapefruit or grapefruit juice. Decreased plasma conc w/ strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampicin, St. John's wort). Interactions w/ substrates of OCT2, MATE1, MATE2-K (eg, metformin) may occur. Interactions w/ narrow therapeutic index P-gp substrates (eg, digoxin or dabigatran etexilate) may occur.
MIMS Class
Targeted Cancer Therapy
ATC Classification
L01EF03 - abemaciclib ; Belongs to the class of cyclin-dependent kinase (CDK) inhibitors. Used in the treatment of cancer.
Presentation/Packing
Form
Verzenio FC tab 100 mg
Packing/Price
56's
Form
Verzenio FC tab 150 mg
Packing/Price
56's
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