Increased risk of hypertensive crisis w/ MAOIs eg, selegiline, isocarboxazid, phenelzine, tranylcypromine. Increased risk of serotonin syndrome w/ serotonergic drugs eg, SSRIs, serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, TCAs, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's wort. Increased exposure w/ CYP2D6 inhibitors eg, paroxetine & fluoxetine, quinidine, ritonavir. Increased blood levels & potentiated action w/ urinary alkalinizing agents eg, acetazolamide, some thiazides. Decreased blood levels & efficacy w/ urinary acidifying agents eg, ammon Cl, Na acid phosphate, methenamine salts. Increased brain conc & potentiated CV effects w/ TCAs eg, desipramine, protriptyline.