Abacavir


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to abacavir. Patients who are positive for HLA-B*57:01 allele. Moderate to severe hepatic impairment. Lactation.
Special Precautions
Patient w/ risk factors for liver disease (e.g. obesity) and those w/ risk factors for coronary heart disease (e.g. HTN, DM, smoking). Renal or mild hepatic impairment. Pregnancy. Monitoring Parameters Monitor blood lipids and glucose reference.
Adverse Reactions
Fever, rash, cough, dyspnoea, lethargy, malaise, headache, myalgia, GI disturbances, particularly nausea, vomiting, diarrhoea and abdominal pain; pancreatitis and elevated liver enzyme values, osteonecrosis, immune reconstitution syndrome, MI, lipodystrophy syndrome. Rarely, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Potentially Fatal: Serious and fatal hypersensitivity reactions w/ multiple organ involvement, lactic acidosis and severe hepatomegaly w/ steatosis.
Drug Interactions
Decreased serum concentrations of methadone. Slightly decreased plasma concentration w/ potent enzymatic inducers (e.g. rifampicin, phenobarbital, phenytoin). Ribavirin may enhance the hepatotoxic effect of nucleoside reverse transcriptase inhibitors.
CIMS Class
ATC Classification
J05AF06 - abacavir ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Disclaimer: This information is independently developed by CIMS based on abacavir from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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