Concise Prescribing Info
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Pain and inflammation associated w/ musculoskeletal and joint disorders; Post-op pain Initial: 120 mg/day in divided doses, may increase to 180 mg.
Should be taken with food. Take w/ or immediately after meals.
Hypersensitivity to acemetacin or indometacin and other NSAIDS. Active or history of peptic ulcer/haemorrhage, history of GI bleeding or perforation related to previous NSAID therapy, blood formation disorder of unclear etiology, nasal polyps (associated w/ angioneurotic oedema), severe heart failure. Severe renal and hepatic impairment. Pregnancy (3rd trimester).
Special Precautions
Patient w/ history of GI toxicity, resp disorder (e.g. asthma, hay fever, swollen nasal mucosae, chronic resp disease), uncontrolled HTN, CHF, ischaemic heart disease, peripheral arterial disease, cerebrovascular disease, hyperlipidaemia, DM, ulcerative colitis, Crohn's disease, SLE, mixed connective tissue disorders, chickenpox, herpes zoster, parkinsonism. Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness, fatigue, and visual disturbances, if affected, do not drive or operate machinery. Monitoring Parameters Monitor haemogram and blood coagulation, liver and kidney function.
Adverse Reactions
Nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, gastritis; asthma, bronchospasm, dyspnoea; pruritus, urticaria, purpura, angioedema; HTN, oedema, cardiac failure; agitation; headache, dizziness, malaise, drowsiness, increased hepatic enzyme; alopecia; retinal pigment degeneration, corneal opacity. Rarely, pancreatitis, exfoliative and bullous dermatoses (e.g. epidermal necrolysis, erythema multiforme); necrotising fasciitis; hyperglycaemia, glucosuria; hyperkalaemia; irritability, confusion.
Potentially Fatal: GI bleeding, ulceration or perforation. Rarely, severe hypersensitivity reactions, including angioneurotic oedema, resp distress which may lead to asthma attack, tachycardia or decreased BP leading to shock.
Drug Interactions
May increase risk of AR w/ other NSAIDs. Increased GI ulceration/bleeding w/ corticosteroids, anti-platelet agents, and SSRIs. Reduced resorption rate w/ antacids. Reduced elimination w/ probenecid, sulfinpyrazone. May reduce the effect of diuretics and antihypertensive agents. May reduce elimination of phenytoin, lithium, methotrexate. Increased risk of nephrotoxicity w/ ciclosporin and diuretics.
ATC Classification
M01AB11 - acemetacin ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.
Disclaimer: This information is independently developed by CIMS based on acemetacin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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