Ampicillin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Susceptible infections 0.25-1 g 6 hrly. UTI 500 mg 8 hrly. Typhoid and paratyphoid fever 1-2 g 6 hrly for 2 wk (acute infections), 4-12 wk (carriers). Uncomplicated gonorrhoea 2 g w/ 1 g of probenecid as single dose. IV Intrapartum prophylaxis against group B Streptoccocal infection Initial: 2 g, then 1 g 4 hrly until delivery. Meningitis 2 g 6 hrly. Intrapleural/IP/IA Supplement in systemic therapy for treatment of susceptible infections 500 mg/day. IM/IV Septicaemia 150-200 mg/kg/day. Start w/ IV admin for 3 days, then IM inj 3-4 hrly. Susceptible infections 500 mg 6 hrly.
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contraindications
Hypersensitivity to ampicillin and other penicillins.
Special Precautions
Patient w/ history of β-lactam allergy. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor renal, hepatic, and haematologic function periodically; observe signs and symptoms of anaphylaxis during 1st dose.
Adverse Reactions
Nausea, vomiting, diarrhoea, erythematous maculo-papular rashes, sore mouth, black/hairy tongue, rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, fever, joint pains, serum sickness-like symptoms, haemolytic anaemia, thrombocytopenia, leucopenia, neutropenia, coagulation disorders, prolonged bleeding time and prothrombin time, CNS toxicity (e.g. convulsions); paraesthesia, nephropathy, interstitial nephritis, hepatitis, cholestatic jaundice, moderate and transient increase in transaminases.
Potentially Fatal: Anaphylaxis, Clostridium difficile-associated diarrhoea (CDAD).
Drug Interactions
May reduce the efficacy of OC. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion w/ probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases ampicillin-induced skin reactions. Reduced absorption w/ chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere w/ the bactericidal action of ampicillin.
CIMS Class
ATC Classification
J01CA01 - ampicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
S01AA19 - ampicillin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
Disclaimer: This information is independently developed by CIMS based on ampicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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