Chlorambucil


Generic Medicine Info
Administration
Should be taken on an empty stomach. Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.
Contraindications
Lactation.
Special Precautions
Patient w/ history of seizure disorder or head trauma, nephrotic syndrome, and those receiving high-pulse therapy. Patient who has recently undergone radiotherapy or received other cytotoxic agents. Admin of live vaccines. Severe hepatic or renal impairment. Childn and elderly. Pregnancy. Monitoring Parameters Perform CBC (w/ differential) wkly while closely monitoring WBC 2 wkly during first 3-6 wk of treatment; and LFTs.
Adverse Reactions
Significant: Myelosuppresion, infertility (i.e. sterility in prepubertal/pubertal males, azoospermia in adult males, amenorrhoea), secondary malignancy (e.g. acute leukaemia). Rarely, focal and/or generalised seizures, erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis. Nervous: Peripheral neuropathy, agitation, ataxia. GI: Nausea, vomiting, diarrhoea, abdominal pain, anorexia, oral ulceration. Resp: Interstitial pneumonia. Hepatic: Hepatotoxicity, jaundice, increased serum alkaline phosphatase and AST levels. Genitourinary: Sterile cystitis. Haematologic: Leucopenia (i.e. neutropenia, lymphopenia), thrombocytopenia, anaemia, pancytopenia, irreversible bone marrow failure. Dermatologic: Rash, urticaria, angioedema, dermatitis, pruritus, occurrence or exacerbation of herpes zoster. Others: Hyperuricaemia, drug fever.
Potentially Fatal: Rarely, pulmonary fibrosis.
CIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01AA02 - chlorambucil ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
Disclaimer: This information is independently developed by CIMS based on chlorambucil from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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