Clomifene

May be taken with or without food.

Abnormal uterine bleeding of unknown origin, ovarian cyst or enlargement not due to polycystic ovarian syndrome, organic intracranial lesion (e.g. pituitary tumour), uncontrolled thyroid or adrenal dysfunction. Active liver disease or history of hepatic impairment. Pregnancy.

Patient w/ uterine fibroids, polycystic ovarian syndrome (PCOS). Lactation. Patient Counselling This drug may cause visual disturbances, dizziness, and lightheadedness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor serum oestrogen prior to therapy. Perform pelvic exam and endometrial biopsy before each course and pregnancy test prior to repeat courses. Monitor for ovulation through basal body temp, ultrasound, serum progesterone, oestradiol, and urinary LH. Assess signs and symptoms of ovarian hyperstimulation syndrome (OHSS).

Significant: Mild to moderate OHSS, visual disturbance (e.g. blurring, scotomata, diplopia, photophobia), endometriosis, ovarian enlargement and cyst formation, risk of multiple or ectopic pregnancy. Rarely, risk of borderline or invasive ovarian cancer. Nervous: Headache, convulsion, restlessness, insomnia, dizziness, vertigo, lightheadedness, depression, nervous tension, fatigue, insomia. GI: Nausea, vomiting, constipation, diarrhoea, increased appetite. Genitourinary: Increased urinary frequency and volume, vag dryness, menorrhagia, uterine haemorrhage, endometriosis. Endocrine: Vasomotor flushes, heavier menses, hypertriglyceridemia, wt gain. Hepatic: Jaundice. Dermatologic: Urticaria, rash, dermatitis, hair loss and dryness. Others: Breast discomfort.
Potentially Fatal: Severe OHSS manifesting as gross ovarian enlargement, pericardial effusion, severe abdominal pain, ascites, dyspnoea, acute resp distress syndrome, hypotension, tachycardia, thromboembolism, hypovolemic shock, and haemoconcentration.

May enhance adverse effect of ospemifene.

Trophic Hormones & Related Synthetic Drugs

G03GB02 - clomifene ; Belongs to the class of synthetic agents used as ovulation stimulants.