Clorazepate


Generic Medicine Info
Contraindications
Hypersensitivity (cross-sensitivity with other benzodiazepines may occur); narrow-angle glaucoma. Patients with depressive or psychotic disorders. child <9 yr. Pregnancy; lactation.
Special Precautions
Elderly, debilitated patients; hepatic disease, alcoholics; renal impairment; resp disease; impaired gag reflex; patients experiencing apnoea during sleep; operating machines or driving; patients on CNS depressant or psychoactive drug therapy; depression, esp those with suicidal tendencies; history of drug-dependence.
Adverse Reactions
Jaundice, hepatic necrosis; extrapyramidal disorders; acute attacks of porphyria in porphyric patients, hypotension; drowsiness, fatigue, ataxia, lightheadedness, memory impairment, insomnia, anxiety, headache, depression, slurred speech, confusion, nervousness, dizziness, irritability; rash; decreased libido; xerostomia, constipation, diarrhoea, decreased salivation, nausea, vomiting, increased or decreased appetite; dysarthria, tremor; blurred vision, diplopia.
Drug Interactions
Potentiates CNS effects of narcotic analgesics, barbiturates, phenothiazines, ethanol, antihistamines, MAO Inhibitors, sedative-hypnotics, cyclic antidepressants. CYP3A4 inhibitors eg, amprenavir, cimetidine, ciprofloxacin, clarithromycin may increase serum conc and toxicity of clorazepate. Carbamazepine, rifampin and rifabutin may decrease clorazepate therapeutic effects by enhancement of clorazepate metabolism.
Disclaimer: This information is independently developed by CIMS based on clorazepate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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