Cycloserine


Generic Medicine Info
Administration
May be taken with or without food. May be taken after meals if GI discomfort occurs.
Contraindications
Hypersensitivity. Patient w/ epilepsy, depression, severe anxiety, psychosis, or in those who misuse alcohol. Severe renal impairment.
Special Precautions
Patient w/ porphyria. Mild to moderate renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor renal, hepatic, and hematological functions; plasma cycloserine concentrations.
Adverse Reactions
Drowsiness, somnolence, dizziness, headache, lethargy, depression, tremor, dysarthria, hyperreflexia, paraesthesia, nervousness, anxiety, vertigo, confusion, disorientation, loss of memory, paresis, major and minor clonic seizures, convulsions, coma; psychosis (possibly w/ suicidal tendencies), personality changes, hyperirritability, aggression; elevated serum aminotransferase levels, esp in patients w/ pre-existing liver disease. Rarely, hypersensitivity reactions including rash and photosensitivity; cardiac arrhythmias and sudden CHF.
Drug Interactions
Concomitant use w/ other anti-TB drugs may lead to vit B12 and/or folic acid deficiency, megaloblastic and sideroblastic anaemia. Increased incidence of CNS effects w/ ethionamide and isoniazid. May inhibit hepatic metabolism of phenytoin.
CIMS Class
ATC Classification
J04AB01 - cycloserine ; Belongs to the class of antibiotics. Used in the systemic treatment of tuberculosis.
Disclaimer: This information is independently developed by CIMS based on cycloserine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in