Daptomycin


Generic Medicine Info
Contraindications
Hypersensitivity.
Special Precautions
Renal impairment. Patient w/ persisting or relapsing Staphylococcus aureus infection. Pregnancy and lactation. Monitoring Parameters Closely monitor for signs and symptoms of eosinophilic pneumonia (e.g. new onset or worsening fever, dyspnoea). Serum creatine kinase should be monitored at least wkly during therapy.
Adverse Reactions
Diarrhoea, vomiting, constipation, nausea, dyspepsia, loose stools, and abdominal pain; pain in extremity, myositis, myopathy, back pain; headache, dizziness, insomnia, anxiety, pharyngolaryngeal pain, pleural effusion; UTI, osteomyelitis, sepsis, bacteraemia, peripheral oedema, pyrexia, chest pain, asthenia, rash, pruritus, erythema, increased sweating, CK elevations, HTN, hyperkalaemia, hypokalaemia, anaemia, hypotension, angioedema, drug rash w/ eosinophilia and systemic symptoms (DRESS). Rarely, jaundice, infusion reactions, rhabdomyolysis, peripheral neuropathy.
Potentially Fatal: Anaphylaxis/hypersensitivity reactions, eosinophilic pneumonia, superinfection including Clostridium difficile-associated diarrhoea and colitis.
Drug Interactions
Enhanced adverse/toxic effects w/ HMG-CoA reductase inhibitors (e.g. simvastatin). NSAIDs (e.g. diclofenac, ibuprofen) may reduce excretion of daptomycin and increase risk of renal impairment. Synergistic antibacterial effects against staphylococci and enterococci w/ aminoglycosides (e.g. gentamicin, tobramycin), rifampicin or β-lactam anti-infectives (e.g. penicillins, cephalosporins).
CIMS Class
ATC Classification
J01XX09 - daptomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on daptomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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