Dolasetron


Generic Medicine Info
Contraindications
Complete heart block (w/o pacemaker), congenital QT syndrome.
Special Precautions
Patient w/ history of abnormal heart rhythms, structural heart disease, sick sinus syndrome, AF w/ slow ventricular response, myocardial ischemia, electrolyte abnormalities (i.e. hypokalaemia, hypomagnesemia). IV admin is not intended for prophylaxis of chemotherapy-associated nausea and vomiting. Pregnancy and lactation. Monitoring Parameters Monitor ECG, serum K and Mg concentration.
Adverse Reactions
Significant: PR, QRS, and QT prolongation. Nervous: Dizziness, headache, drowsiness, fatigue, syncope, flushing, paraesthesia, tremor, ataxia, twitching, agitation, anxiety, sleep disorder, depersonalization, confusion, abnormal dreaming. CV: Bradycardia, HTN, orthostatic hypotension, tachycardia, peripheral oedema and ischaemia, phlebitis. GI: Diarrhoea, dyspepsia, flatulence, taste disturbance, constipation, abdominal pain, anorexia, pancreatitis. Resp: Bronchospasm, dyspnea, epistaxis. Genitourinary: Oliguria, dysuria, polyuria, acute renal failure, urinary retention, hematuria. Haematologic: Anemia, hematoma, thrombocytopenia, prolonged partial thromboplastin time (PTT) and prothrombin time. Musculoskeletal: Myalgia, arthralgia. Ophthalmologic: Abnormal vision, photophobia. Otic: Tinnitus. Dermatologic: Pruritus, urticaria, increased sweating, rash. Others: Chills, fever, pain, pain at inj site.
Potentially Fatal: Serotonin syndrome. Rarely, cardiac arrest, 2nd or 3rd degree AV block, serious ventricular arrhythmia (e.g. torsade de pointes).
Drug Interactions
Increased risk of QT prolongation w/ other QT prolonging agents (e.g. pimozide, ziprasideone) and drugs known to cause electrolyte imbalance (e.g. diuretics). Decreased blood levels and therapeutic effects w/ rifampicin. Increased blood levels and effects w/ atenolol and cimetidine. Increased risk of conduction abnormalities when concurrently used w/ antiarrhythmic agents (e.g. verapamil, flecainide, quinidine).
CIMS Class
ATC Classification
A04AA04 - dolasetron ; Belongs to the class of serotonin (5HT3) antagonists. Used for the prevention of nausea and vomiting.
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