Donepezil


Generic Medicine Info
Administration
May be taken with or without food.
Special Precautions
Patient w/ history of asthma or COPD, sick sinus syndrome, supraventricular conduction abnormalities, susceptibility to peptic ulcer, seizures, GI or urinary tract obstruction. Hepatic impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor mental status, wt, pulse, symptoms of GI intolerance or bleeding.
Adverse Reactions
Diarrhoea, muscle cramps, fatigue, nausea, vomiting, headache, insomnia, abnormal dreams, common cold, aggression, agitation, anorexia, dizziness, hallucinations, pruritus, rash, syncope, urinary incontinence, bradycardia, duodenal/gastric ulcers, GI haemorrhage, seizures. Rarely, AV block, extrapyramidal symptoms, hepatitis, bladder outflow obstruction, sino-atrial block.
Potentially Fatal: Rarely, neuroleptic malignant syndrome.
Drug Interactions
Increased risk of neuroleptic malignant syndrome w/ antipsychotics. Synergistic effect w/ succinylcholine, similar neuromuscular blocking agents, or cholinergic agonists (e.g. bethanechol). May interfere w/ the activity of anticholinergic medications. Increased plasma concentration when used w/ CYP3A4 inhibitors (e.g. ketoconazole, erythromycin) and CYP 2D6 inhibitors (e.g. fluoxetine, quinidine). Decreased plasma concentrations w/ enzyme inducers (e.g. rifampicin, phenytoin).
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Disclaimer: This information is independently developed by CIMS based on donepezil from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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