Doxazosin


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Patient w/ history of orthostatic hypotension; benign prostatic hyperplasia and concomitant congestion of the upper urinary tract, chronic urinary tract infection or bladder stones; monotherapy in patients w/ either overflow bladder or anuria w/ or w/o progressive renal insufficiency.
Special Precautions
Prostatic carcinoma should be ruled out before starting therapy. Hepatic impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive and operate machinery. Monitoring Parameters Monitor BP and renal function.
Adverse Reactions
Orthostatic hypotension may occur at the initiation of therapy or during dose increase, Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery, hypotension, syncope, palpitations, chest pain, dizziness, headache, drowsiness, lethargy, fatigue, nausea, abdominal pain, diarrhoea, dry mouth, oedema, rhinitis, dyspnoea, arthralgia/arthritis, muscle weakness, myalgia, muscle cramps, pruritus, rash, facial oedema, polyuria, urinary incontinence, visual abnormalities, tinnitus; reduced leukocyte and neutrophil counts. Rarely, priapism can occur.
Drug Interactions
Concomitant admin w/ phosphodiesterase type 5 (PDE-5) inhibitors (e.g. sildenafil) may lead to symptomatic hypotension. Potentiates the BP lowering activity of other α-blockers and other antihypertensives.
ATC Classification
C02CA04 - doxazosin ; Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.
Disclaimer: This information is independently developed by CIMS based on doxazosin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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