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Indications/Uses
Palliation of prostatic carcinoma.
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Dosage/Direction for Use
Adult: PO 250 mg 3 times/day.
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Administration
May be taken with or without food.
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Contraindications
Hypersensitivity, severe hepatic impairment, pregnancy and lactation.
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Special Precautions
Perform liver function tests before starting treatment and at regular intervals. Treatment is not recommended in patients whose ALT values exceed twice the upper limit of normal. Regular assessment of prostate specific antigen level may help to monitor disease progression. Advise patient against discontinuing drug on their own. Exercise caution in patients with cardiac disease.
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Adverse Reactions
Hot flushes, loss of libido, impotence, gynaecomastia, nausea, vomiting, diarrhoea, increased appetite, sleep disturbances, skin reactions, anaemias, headache, dizziness, malaise, anxiety, hypertension, gastric and chest pain, oedema, blurred vision, hepatitis, jaundice, rash, thirst, pruritus, SLE-like syndrome, drowsiness, confusion, depression, nervousness.
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Drug Interactions
Increased prothrombin time in patients on long-term warfarin treatment.
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CIMS Class
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ATC Classification
L02BB01 - flutamide ; Belongs to the class of anti-androgens.
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