Guanfacine


Generic Medicine Info
Special Precautions
Patient w/ history of hypotension, heart block, bradycardia, CV disease, history of syncope or conditions which may predispose them to syncope (e.g. dehydration), history of QT prolongation, risk factors for torsade de pointes. Avoid abrupt withdrawal. Renal or hepatic impairment. Childn. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, somnolence, and syncope, if affected, do not drive or operate machinery. Monitoring Parameter Monitor heart rate, BP and consider ECG prior to initiation.
Adverse Reactions
Somnolence, bradycardia, hypotension, abdominal pain, dry mouth, dizziness, headache, constipation, depression, anxiety, fatigue, nausea, vomiting, diarrhoea, enuresis, impotence, orthostatic hypotension, decreased appetite, insomnia, nightmare, sedation, lethargy, irritability, rash.
Drug Interactions
Additive effect w/ diuretics, other antihypertensives, CNS depressants. Phenobarbital and phenytoin may decrease elimination half-life and plasma concentration of guanfacine for renally impaired patients. Additive sedative effect w/ centrally active depressants (e.g. phenothiazines, barbiturates, benzodiazepines). Increased plasma concentrations w/ CYP3A4/5 inhibitors (e.g. ketoconazole). Decreased rate and extent of exposure w/ CYP3A4 inducers (e.g. rifampicin).
CIMS Class
Other Antihypertensives / Other CNS Drugs & Agents for ADHD
ATC Classification
C02AC02 - guanfacine ; Belongs to the class of imidazoline receptor agonists, centrally-acting antiadrenergic agents. Used in the treatment of hypertension.
Disclaimer: This information is independently developed by CIMS based on guanfacine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in