Halofantrine


Generic Medicine Info
Contraindications
Existing or family history of prolonged QT-interval; cardiac disease; unexplained syncopal attacks; thiamine deficiency; electrolyte disturbances or taking arrhythmogenic drugs; previous or concurrent treatment with mefloquine; hypersensitivity; pregnancy; lactation.
Special Precautions
Chronic liver disease; baseline EKG should be performed; haematocrit and Hb level must be monitored closely. Fatty food should be avoided for 24 hr after admin of halofantrine to prevent increase in bioavailability and thus risk of toxicity. Cardiac rhythm should be monitored during and for 8-12 hr after completion of treatment.
Adverse Reactions
Diarrhoea, abdominal pain, nausea, vomiting, pruritis, skin rash; hypersensitivity reactions; intravascular haemolysis.
Potentially Fatal: Serious ventricular arrhythmias.
Drug Interactions
Drugs that cause electrolyte disturbances e.g. diuretics. Mefloquine; drugs that induce arrhythmia eg, chloroquine, quinine, TCAs; some antiarrhythmics (amiodarone, dysopyramide, flecainide, procainamide, quinidine and sotalol), cisapride, astemizole and terfenadine.
CIMS Class
Antimalarials
ATC Classification
P01BX01 - halofantrine ; Belongs to the class of other antimalarials. Used in the management of malaria.
Disclaimer: This information is independently developed by CIMS based on halofantrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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