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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Hypertension Monotherapy or in combination with other antihypertensive agents: As levamlodipine maleate/besylate: Initial: 2.5 mg once daily. Angina pectoris As levamlodipine besylate: 2.5 mg once daily. All doses may be increased as necessary according to patient response. Max: 5 mg once daily.
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Special Precautions
Patient with severe aortic stenosis; severe obstructive coronary artery disease, heart failure with reduced ejection fraction, hypertrophic cardiomyopathy and outflow tract obstruction. Hepatic impairment. Children and elderly. Pregnancy and lactation. Monitoring Parameters Monitor heart rate and blood pressure.
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Adverse Reactions
Significant: Worsening angina, acute MI, reflex tachycardia, symptomatic hypotension.
Cardiac disorders: Dyspnoea, palpitation.
Gastrointestinal disorders: Nausea, abdominal pain.
General disorders and administration site conditions: Fatigue, asthenia.
Hepatobiliary disorders: Jaundice.
Investigations: Increased liver enzymes.
Metabolism and nutrition disorders: Peripheral oedema.
Musculoskeletal and connective tissue disorders: Muscle cramps.
Nervous system disorders: Dizziness, extrapyramidal disorder.
Psychiatric disorders: Somnolence, insomnia.
Reproductive system and breast disorders: Sexual dysfunction, gynaecomastia.
Skin and subcutaneous tissue disorders: Rash, pruritus.
Vascular disorders: Flushing.
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Drug Interactions
May increase serum concentrations with moderate and strong CYP3A4 inhibitors. May increase the serum levels of simvastatin, lovastatin, immunosuppressants (e.g. ciclosporin, tacrolimus).
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CIMS Class
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