Lisinopril


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
History of angioedema related to previous ACE inhibitor treatment, hereditary or idiopathic angioedema. Concomitant use with aliskiren especially in patients with diabetes mellitus or renal impairment (GFR<60 mL/min/1.73 m2). Concomitant use with sacubitril. Pregnancy.
Special Precautions
Patient with severe aortic stenosis, hypertrophic cardiomyopathy, CV disease (e.g. ischaemic heart disease) collagen vascular disease, ascites, unstented unilateral and bilateral renal artery stenosis. Patient undergoing major surgery or during anaesthesia. Black race. Desensitisation treatment (e.g. hymenoptera venom). Renal and hepatic impairment. Lactation. Children. Patient Counselling This drug may cause occasional dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor BP, heart rate, BUN, CBC with differential LFT, serum K, and creatinine levels. Assess for signs of angioedema.
Adverse Reactions
Significant: Hyperkalaemia, hypotension, cholestatic jaundice, chest pain, syncope, cough, haematologic effects (e.g. neutropenia, anaemia, thrombocytopenia). Cardiac disorders: Tachycardia, palpitations. Ear and labyrinth disorders: Tinnitus. Gastrointestinal disorders: Nausea, diarrhoea, vomiting, abdominal pain, dry mouth, constipation. General disorders and administration site conditions: Fatigue, asthenia. Investigations: Elevated serum creatinine, BUN increased. Metabolism and nutrition disorders: Electrolyte imbalance. Musculoskeletal and connective tissue disorders: Arthralgia, myalgia. Nervous system disorders: Headache, vertigo, paresthesia, taste disturbance, dizziness. Psychiatric disorders: Hallucinations, mood alterations, sleep disturbance, drowsiness. Renal and urinary disorders: Renal dysfunction, oliguria, anuria. Reproductive system and breast disorders: Impotence, gynaecomastia. Respiratory, thoracic and mediastinal disorders: Rhinitis, sinusitis, dyspnoea. Skin and subcutaneous tissue disorders: Pruritus, rash, psoriasis. Vascular disorders: Raynaud's phenomenon, flushing.
Potentially Fatal: Anaphylactoid reactions (e.g. angioedema of face, lips, tongue, and extremities), arrhythmia, severe hypotension. Rarely, fulminant hepatic necrosis.
Drug Interactions
Increased hypotensive effect with antihypertensives, diuretics. Increased risk of hyperkalaemia with K-sparing diuretics (e.g. spironolactone, amiloride), K supplements, and drugs affecting serum K concentrations (e.g. trimethoprim, ciclosporin). May increase hypoglycaemic effect with insulin and oral hypoglycaemics agents. Concomitant use with NSAIDs including selective COX-2 inhibitors may result to renal function deterioration and reduced antihypertensive effect. May increase serum levels and toxicity of lithium. Coadministration with parenteral gold (e.g. Na aurothiomalate, aurothioglucose) may cause nitritoid reaction characterized by facial flushing, nausea, vomiting, and hypotension. Increased risk of angioedema with mammalian target of rapamycin (mTOR) inhibitors (e.g. temsirolimus, sirolimus, everolimus), tissue plasminogen activators (e.g. alteplase), neprilysin inhibitors (e.g. sacubitril) and neutral endopeptidase (NEP) inhibitors (e.g. racecadotril).
ATC Classification
C09AA03 - lisinopril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
Disclaimer: This information is independently developed by CIMS based on lisinopril from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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