Methenamine


Generic Medicine Info
Contraindications
Hypersensitivity. Gout, metabolic acidosis, severe dehydration. Renal and severe hepatic impairment. Concomitant use w/ sulfonamides or alkalinising agents.
Special Precautions
Patient w/ indwelling urinary catheters; conditions wherein urine acidification is contraindicated or unattainable (e.g. presence of urea-splitting bacteria in the urine). Mild to moderate hepatic impairment. Childn. Pregnancy and lactation. Not intended for use in upper UTI. Monitoring Parameters Monitor urinalysis, urine culture, LFT. Maintain an acidic urine, or give supplemental acidification (e.g. ammonium Cl, ascorbic acid, methionine), if necessary.
Adverse Reactions
Significant: Increased ALT/AST, dysuria. GI: Dyspepsia, nausea, vomiting, diarrhoea. Genitourinary: Bladder irritation, painful/frequent micturition, albuminuria, haematuria. Dermatologic: Rash, pruritus.
Drug Interactions
Acetazolamide may inhibit conversion of methenamine into formaldehyde.
CIMS Class
ATC Classification
J01XX05 - methenamine ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
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